Effect of H2 Receptor Antagonist and Proton Pump Inhibitor on the Positivity Rates and Clinical Outcomes of COVID-19
- Conditions
- COVID-19
- Registration Number
- NCT04834752
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
This retrospective cohort study aims to evaluate the effect of proton pump inhibitor (PPI) or histamine-2 receptor antagonist (H2RA) on the clinical outcomes and positivity rates of Coronavirus Disease-19 (COVID-19).
- Detailed Description
Previous researches on the association between the use of PPI and H2RA and the treatment and prevention of COVID-19 have reported inconsistent findings. This study aimed to evaluate the effect of H2 receptor antagonists and proton pump inhibitors on the clinical outcomes and positivity rates of COVID-19 using the Korean National Health Insurance (NHI) data. This is a retrospective cohort study using the NHI COVID-19 dataset, which includes health insurance data of individuals who underwent COVID-19 PCR test in South Korea. This study aims to evaluate the effect of the use of PPI and H2RA on the positivity rates and clinical outcomes of COVID-19.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 400000
- Individuals who were tested for COVID-19 using real-time reverse transcriptase PCR assay of nasal and pharyngeal swabs
- Record of a new prescription of non-steroidal anti-inflammatory drugs (NSAID) within 1 month of the test date
- Patients who died within 48 hours after test.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality 60 days Mortality of participants who died after diagnosis of COVID-19 (during the hospitalization or after discharge)
COVID-19 test positivity Through test completion, an average of 1 day Test positivity rates for COVID-19 nasopharyngeal polymerase chain reaction (PCR): number of participants diagnosed with COVID-19 compared to the number participants who were tested for COVID-19
- Secondary Outcome Measures
Name Time Method Rates of vasopressor and inotrope use 60 days Rates of vasopressor and inotrope use of patients who were diagnosed with COVID-19
Intensive care unit admission rate 60 days Intensive care unit admission rate of patients who were diagnosed with COVID-19
Mechanical ventilator application rate 60 days Mechanical ventilator application rate of patients who were diagnosed with COVID-19
Oxygen apply rate (Nasal prong, Facial Mask, High flow nasal cannula) 60 days Oxygen apply (Nasal prong, Facial Mask, High flow nasal cannula) rates of patients who were diagnosed with COVID-19
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic of