Effect of Histamine 2 Receptor Antagonist (H2RA) and Proton Pump Inhibitor (PPI) on the Positivity Rates and Clinical Outcomes of Coronavirus Disease-19 (COVID-19).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 400,000
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
This retrospective cohort study aims to evaluate the effect of proton pump inhibitor (PPI) or histamine-2 receptor antagonist (H2RA) on the clinical outcomes and positivity rates of Coronavirus Disease-19 (COVID-19).
详细描述
Previous researches on the association between the use of PPI and H2RA and the treatment and prevention of COVID-19 have reported inconsistent findings. This study aimed to evaluate the effect of H2 receptor antagonists and proton pump inhibitors on the clinical outcomes and positivity rates of COVID-19 using the Korean National Health Insurance (NHI) data. This is a retrospective cohort study using the NHI COVID-19 dataset, which includes health insurance data of individuals who underwent COVID-19 PCR test in South Korea. This study aims to evaluate the effect of the use of PPI and H2RA on the positivity rates and clinical outcomes of COVID-19.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals who were tested for COVID-19 using real-time reverse transcriptase PCR assay of nasal and pharyngeal swabs
排除标准
- •Record of a new prescription of non-steroidal anti-inflammatory drugs (NSAID) within 1 month of the test date
- •Patients who died within 48 hours after test.
结局指标
主要结局
Mortality
时间窗: 60 days
Mortality of participants who died after diagnosis of COVID-19 (during the hospitalization or after discharge)
COVID-19 test positivity
时间窗: Through test completion, an average of 1 day
Test positivity rates for COVID-19 nasopharyngeal polymerase chain reaction (PCR): number of participants diagnosed with COVID-19 compared to the number participants who were tested for COVID-19
次要结局
- Rates of vasopressor and inotrope use(60 days)
- Oxygen apply rate (Nasal prong, Facial Mask, High flow nasal cannula)(60 days)
- Intensive care unit admission rate(60 days)
- Mechanical ventilator application rate(60 days)
研究者
Soo-Jeong Cho
Clinical associate professor
Seoul National University Hospital