Study on Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus

Recruiting

• Conditions: Prenatal Diagnosis and Closed-loop Management System of Congenital Talipes Equinovarus

• Registration Number: NCT05638490
• Lead Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Brief Summary

The study intends to establish a closed-loop management from prenatal to postnatal through prospective cohort, and comprehensively utilize ultrasound and MRI technology to establish a prenatal diagnosis and evaluation system for congenital talipes equinovarus. On the basis of existing genetic testing, further use of whole-exome sequencing and other genomic methods to explore possible pathogenic genes and loci, and clarify the pathogenic mechanism of congenital talipes equinovarus. Therefore, congenital talipes equinovarus can improve its diagnosis and treatment capacity, reduce the disability rate related to congenital talipes equinovarus, and prevent it well.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-03
• Status Verified: 2022-11
• Study First Submitted: 2022-11-17
• Study First Submitted QC: 2022-11-27
• Last Update Submitted: 2022-11-27
• Study First Posted: 2022-12-06
• Last Update Posted: 2022-12-06
• Primary Completion: 2024-08
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

1）Single pregnant women 2) "congenital talipes equinovarus" suggested by ultrasound

Exclusion Criteria

Twin or multiple pregnancies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Genetic testing results of congenital talipes equinovarus	2 years	chromosomal microarray analysis or whole exome screening to find genetic abnormalities of congenital talipes equinovarus

Trial Locations

Locations (1)

Drum Tower hospital; 🇨🇳 Nanjing, Jiangsu, China