Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: a Functional Near-infrared Spectroscopy Study
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Dingqun Bai
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients
Overview
Brief Summary
This is an fNIRS study performed to investigate Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients.
Detailed Description
This was an initial screening and preliminary intervention study. Both healthy subject and stroke patients will be included in this study. Brain functional activation of each subject during Immersive Virtual Reality Pathfinding Task will be evaluated using functional near-infrared spectroscopy (fNIRS). Cognitive function related scale assessment included Mental State Examination Scale (MMSE), Montreal Cognitive Assessment (MoCA), drawing clock test (DCT), Shape trials test A.B (STT-A, STT-B), standardized digital modal test (SDMT), auditory verbal learning test-Huashan version (AVLT-H), and activity of daily living (ADL) scale will be used to evaluate the function of each patient. Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task will be identified by by comparing differences in brain activation and brain network connectivity between patients and healthy subjects.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Stroke patients:
- •Diagnosis of stroke confirmed by neuroimaging (CT or MRI)
- •18-80 years old
- •Able to complete the cognitive task
- •Able to follow instructions to complete the trial
- •Patients who signed an informed consent form.
- •Healthy Subjects:
- •No abnormalities on cranial
- •18-80 years old
- •Able to complete cognitive task
Exclusion Criteria
- •Stroke patients:
- •Inability to tolerate the test due to organic diseases
- •Serious mental illness that prevents them from cooperating with or tolerating the trial
- •Pregnant or lactating women
- •Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction.
- •Healthy Subjects:
- •Inability to tolerate the test due to organic diseases
- •Serious mental illness that prevents them from cooperating with or tolerating the trial.
- •Pregnant or lactating women
- •Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction
Outcomes
Primary Outcomes
Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients
Time Frame: 1 day
Comparison of differences in brain activation \[HbO2 (mmol/L\*mm)\] between patients with post-stroke cognitive impairment and patients without post-stroke cognitive impairment or healthy subjects during Immersive Virtual Reality Pathfinding Task.
Secondary Outcomes
No secondary outcomes reported
Investigators
Dingqun Bai
Director of rehabilitation Medicine
First Affiliated Hospital of Chongqing Medical University