Clinical trial comparing the effects of Pistacia atlantica oleoresin and placebo on the joint pain and stiffness and physical function in the knee osteoarthritis patients

Vice Chancellor for Research, ACECR Institute of Medicinal Plants0 个研究点目标入组 100 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

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•male or female patients with 1 or 2 knees osteoarthritis according to the American College of Rheumatology criteria after physical examination and knee joint radiography, age of 40 to 85 years, flare of the disease after oral non-steroidal anti-inflammatory drug or acetaminophen discontinuation which have been used at least 3 days a week during the past month (flare means increase of at least 2 scores in the total pain subscale score in the beginning of the study.), Western Ontario and McMaster Universities (WOMAC) pain subscale index at least 9 out of 20 in the beginning of the study. Exclusion criteria: secondary osteoarthritis (due to a definite disease); arthroscopy; surgery; knee joint injection during the past 6 months; history of knee replacement surgery; any serious systemic disease (such as concomitant infections, cardiovascular, hepatic and renal diseases); any other chronic inflammatory disease; intake of any other supplement except multivitamin; intake of non-steroidal anti-inflammatory drugs; intake of any steroidal drug, skeletal muscle relaxing drug, anti-depressant drugs, glucosamine, chondroitin, tramadol and topical analgesic drugs like capsaicin and generally any analgesic drug; any history of alcohol, drug and narcotics abuse; skin disease at the site of topical use of the oleoresin or placebo (knee); having fibromyalgia and other debilitating diseases affecting the knee; pregnant women; women planning pregnancy; lactating women.

发起方

Vice Chancellor for Research, ACECR Institute of Medicinal Plants