PC-based Rehabilitation of Motor Planning Deficits in Parkinson Disease
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 54
- 主要终点
- Reaction Time and Variability for Movement Task
研究概览
简要总结
We are testing a computer game-style rehabilitation program for people with Parkinson's disease (PD). People with PD often have difficulty with motor planning, such as initiating or starting movements. We believe that our program will improve performance on a movement initiation task as well as on activities of daily living, such as walking, preparing a meal or opening a medicine bottle. We will measure brain function using functional MRI before and after training to identify brain areas that are involved in improved performance. If effective, computer based training will be an inexpensive treatment for motor planning deficits in PD that is free from side effects and easy to administer to a large number of patients.
详细描述
Our approach is to use PD-based adaptive training to improve performance on IG movement initiation in patients with PD. We have three aims, 1) to systematically evaluate cognitive rehabilitation in people with Parkinson's disease (PD), 2) to examine the neural mechanisms subserving cognitive rehabilitation in PD and 3) to assess the ecological validity of cognitive rehabilitation in PD. We will focus on a single aspect of cognitive function, the decision to initiate a movement. Movements can be internally generated (IG) or externally cued, and motor deficits in PD are typically linked to IG movements. The protocol is designed to drive beneficial neuroplastic changes using a paradigm similar to those that have shown promising results in traumatic brain injury patients. In addition, we will use fMRI to measure activity in underlying basal ganglia-thalamocortical circuits. Finally, because the goal of any research regarding the pathophysiology of disease is to improve the lives of patients with the disease, behavioral and neuropsychological measures will be correlated with fMRI measured functional abnormalities before and after training. Improvement in the initiation of movement has the potential to dramatically improve daily functioning including reducing falls, improving language production and improving proficiency of activities of daily living.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of PD dominant on the right side with a Hx of response to dopamine replacement.
排除标准
- •Contraindication to MRI
- •History of stroke or significant head trauma
- •Significant vision impairment
- •Hx of brain surgery or claustrophobia
- •Medication change <4 weeks
- •Atypical PD
- •Severe tremor
- •Presence of motor fluctuations or dyskinesia
- •Significantly impaired limb or joint function
- •Significant memory impairment
- •Depression or daytime sleepiness
结局指标
主要结局
Reaction Time and Variability for Movement Task
时间窗: time of enrollment and 2 months following enrollment (before and after training)
Before and after computer training outcome measures: left, right, bimanual external cue reaction time; left, right, bimanual external cue error; left, right, bimanual internally generated reaction time; left, right, bimanual internally generated error for four-digit trials.
次要结局
- Symbol Digit Modality Test (SDMT)(time of enrollment and 2 months following enrollment (before and after training))
- Neuropsychological Measures of Cognitive Function, Including Reaction Time and Time to Completion(time of enrollment and 2 months following enrollment (before and after training))
- Task Errors and Variability(time of enrollment and 2 months following enrollment (before and after training))
- Functional Dexterity Test (FDT)(time of enrollment and 2 months following enrollment (before and after training))