Renal doppler and renal biomarker for prediction of acute kidney injury in patients with severe preeclampsia

Not Applicable

• Conditions: severe preeclampsia; Kidney Disease; Pregnancy and Childbirth

• Registration Number: PACTR202001671840885
• Lead Sponsor: alexandria faculty of medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-02
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

Severe preeclampsia, blood pressure: 160 mm Hg or higher systolic or 110 mm Hg or higher diastolic
Proteinuria: 5 g or more of protein in a 24-hour urine collection or 3+ or greater on urine dipstick testing
Cerebral or visual disturbances
Epigastric or right upper quadrant pain

Exclusion Criteria

1.Patients with preexisting renal insufficiency.
2.Patients with a history of dialysis requirement.
3.Diabetes mellitus, essential hypertension and peripheral vascular disease.
4.Use of nephrotoxic drugs before or during the study period.
5.Patients with elevated serum urea and creatinine at time of admission.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evaluate the efficacy of renal resistance indices (RRIs) and neutrophil gelatinase-associated lipocalin (NGAL) for early prediction of occurrence and severity of acute kidney injury in patients with severe preeclampsia.

Secondary Outcome Measures

Name	Time	Method
establish a cut-off value for various renal resistance indices and neutrophil gelatinase-associated lipocalin for early prediction of acute kidney injury in patients with severe preeclampsia.