Effect of Chronic PDE5-Inhibition on Endothelial Function in Diabetics

Phase 3

Completed

• Conditions: Diabetes

• Registration Number: NCT00420901
• Lead Sponsor: IRCCS San Raffaele

Brief Summary

chronic PDE5-Inhibition improves endothelial function in diabetics

Detailed Description

Evaluation of endothelial function at baseline and after chronic administration of sildenafil in male subjects with diabetes

Study Timeline

• Study Start: 1999-01
• Study Completion: 2000-02
• Status Verified: 2007-01
• Study First Submitted: 2007-01-09
• Study First Submitted QC: 2007-01-09
• Last Update Submitted: 2007-01-09
• Study First Posted: 2007-01-11
• Last Update Posted: 2007-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• type 2 diabetes
• males

Exclusion Criteria

• females, nitrate use, PDE5-Inhibitors intolerance

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Endothelial function responders - Improvement in endothelial function

Secondary Outcome Measures

Name	Time	Method
Changes in vascular inflammatory markers

Trial Locations

Locations (1)

San Raffaele EUR; 🇮🇹 Roma, Italy