Evaluation of Different Anesthesia for Uterine Curettage

Not Applicable

Completed

• Conditions: Abortion, Induced; Uterine Curettage
• Interventions: Drug: Sevoflurane; Drug: Lidocaine; Drug: Propofol

• Registration Number: NCT00733564
• Lead Sponsor: Nanjing Medical University

Brief Summary

Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's "easy come, easy go" property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-08
• Study First Submitted: 2008-08-11
• Study First Submitted QC: 2008-08-12
• Study First Posted: 2008-08-13
• Status Verified: 2009-03
• Primary Completion: 2009-03
• Study Completion: 2009-03
• Last Update Submitted: 2009-03-30
• Last Update Posted: 2009-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

• ASA status I-II
• Performing abortion operation (medical- or surgical)
• Requiring painless abortion

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Exclusion Criteria

• < 19 yrs, and >=45 yrs
• History of central active drugs administration
• Drug abuse
• Hypertension
• Diabetes
• Any other chronic diseases
• Allergy to the study drugs
• Habit of over-volume alcohol drinking
• Records of history of centrally active drug use and psychiatry
• Any organic disorder

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
3	Sevoflurane	Sevoflurane anesthesia will be performed
1	Lidocaine	Paracervical block will be performed
2	Propofol	Propofol anesthesia will be performed

Primary Outcome Measures

Name	Time	Method
Bispectral Index (BIS) value	0, 5, 10, 20, 30min after anesthesia

Secondary Outcome Measures

Name	Time	Method
Side effects	30min after operation
Pain intensity	0, 5, 10, 20, 30min after surgical procedures
Arterial blood gas analysis	5min before operation; 1min and 5min after beginning of the operation
Cortisol level	30min before operation; 1 and 5min during operation
Intraoperative awareness	0, 5, 10, 20, 30min after anesthesia
Vital signs	0, 5, 10, 15, 20, 25, 30min after anesthesia
Uterine bleeding	0min after completion of the operation; 1 hour after the operation

Trial Locations

Locations (1)

Nanjing Maternal and Child Health Care Hospital; 🇨🇳 Nanjing, Jiangsu, China