Evaluation of the Anesthetic Efficacy of Propofol,Sevoflurane and Paracervical Block for Uterine Curettage
Overview
- Phase
- Not Applicable
- Intervention
- Lidocaine
- Conditions
- Uterine Curettage
- Sponsor
- Nanjing Medical University
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- Bispectral Index (BIS) value
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's "easy come, easy go" property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA status I-II
- •Performing abortion operation (medical- or surgical)
- •Requiring painless abortion
Exclusion Criteria
- •\< 19 yrs, and \>=45 yrs
- •History of central active drugs administration
- •Drug abuse
- •Hypertension
- •Any other chronic diseases
- •Allergy to the study drugs
- •Habit of over-volume alcohol drinking
- •Records of history of centrally active drug use and psychiatry
- •Any organic disorder
Arms & Interventions
1
Paracervical block will be performed
Intervention: Lidocaine
2
Propofol anesthesia will be performed
Intervention: Propofol
3
Sevoflurane anesthesia will be performed
Intervention: Sevoflurane
Outcomes
Primary Outcomes
Bispectral Index (BIS) value
Time Frame: 0, 5, 10, 20, 30min after anesthesia
Secondary Outcomes
- Pain intensity(0, 5, 10, 20, 30min after surgical procedures)
- Arterial blood gas analysis(5min before operation; 1min and 5min after beginning of the operation)
- Cortisol level(30min before operation; 1 and 5min during operation)
- Intraoperative awareness(0, 5, 10, 20, 30min after anesthesia)
- Vital signs(0, 5, 10, 15, 20, 25, 30min after anesthesia)
- Uterine bleeding(0min after completion of the operation; 1 hour after the operation)
- Side effects(30min after operation)