Evaluation of the Anesthetic Efficacy of Propofol,Sevoflurane and Paracervical Block for Uterine Curettage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Bispectral Index (BIS) value
研究概览
简要总结
Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's "easy come, easy go" property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA status I-II
- •Performing abortion operation (medical- or surgical)
- •Requiring painless abortion
排除标准
- •< 19 yrs, and >=45 yrs
- •History of central active drugs administration
- •Drug abuse
- •Hypertension
- •Any other chronic diseases
- •Allergy to the study drugs
- •Habit of over-volume alcohol drinking
- •Records of history of centrally active drug use and psychiatry
- •Any organic disorder
研究组 & 干预措施
1
Paracervical block will be performed
干预措施: Lidocaine (Drug)
2
Propofol anesthesia will be performed
干预措施: Propofol (Drug)
3
Sevoflurane anesthesia will be performed
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Bispectral Index (BIS) value
时间窗: 0, 5, 10, 20, 30min after anesthesia
次要结局
- Pain intensity(0, 5, 10, 20, 30min after surgical procedures)
- Arterial blood gas analysis(5min before operation; 1min and 5min after beginning of the operation)
- Cortisol level(30min before operation; 1 and 5min during operation)
- Intraoperative awareness(0, 5, 10, 20, 30min after anesthesia)
- Vital signs(0, 5, 10, 15, 20, 25, 30min after anesthesia)
- Uterine bleeding(0min after completion of the operation; 1 hour after the operation)
- Side effects(30min after operation)