ADD-ON EFFECT OF DRAKSHARISTA TO THIAMINE IN THE MANAGEMENT OF ALCOHOL USE DISORDER-A RANDOMIZED DOUBLE BLIND CONTROLLED STUDY

As per Ayurvedic texts, the disease caused by the abuse of alcohol is called Madatyaya, which presents with clinical features similar to alcoholism. Madatyaya is a Tridoshaj disorder with Vataj, Pitta, Kapha, and Sannipataj types. Treatment typically begins at the site of Kapha, as it is predominantly affected, along with Pitta and Vata.

Alcohol Use Disorder (AUD) is characterized by a strong internal drive to consume alcohol, impaired control over use, prioritization of alcohol over other activities, and persistence despite harmful consequences. People with AUD are at increased risk of liver cirrhosis, pancreatic disease, and accidents. Globally and in India, AUD contributes significantly to morbidity and mortality, with a large proportion of affected individuals requiring treatment.

Excessive alcohol consumption directly affects the Hriday, impacting both physical and psychological health through the Rasavaha and Manovaha Srotas. Conventional management of AUD ranges from psychotherapy to pharmacological interventions, but these drugs often have contraindications, and a universally effective treatment is lacking.

Ayurvedic therapies have shown protective effects on alcohol dependence, withdrawal anxiety, and liver health, acting as hepatoprotective and antioxidant agents. In Ayurveda, Madatyaya involves vitiation of both Shareerika and Manasika Doshas, affecting physical, psychological, social, and occupational well-being. Management primarily includes Doshavsechana, Rasayana, and Satvavajaya Chikitsa. Preparations like Karjuradhi Mantha have Rasayana and Ojovardhana properties, while Virechana aids in Dosha elimination, pitta reduction, and gut microbiota improvement.

The present study has been designed to evaluate an integrative Ayurvedic treatment protocol, including Satvavajaya Chikitsa, pathya-apathya, and a Yoga regimen, for the management of Madatyaya (alcohol dependence).