Cerebral oxygen dependency in acute ischemic stroke

• Conditions: ischemic stroke - infarction; 10003216

• Registration Number: NL-OMON31314
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

Eligible for inclusion are patients with acute first stroke. Ischemic stroke is defined as a clinical syndrome of rapid onset of a non-convulsive and focal or global neurological cerebral deficit with a vascular cause persisting for >24 hours without signs of a cerebral hemorrhage on computed tomography (CT) scan. Subjects, or a direct relative, will receive verbal and written explanation of the objectives and techniques of measurements and risks associated with the study. Written informed consent will be provided in accordance with the Helsinki Declaration.

Exclusion Criteria

Patients are considered not eligible in case of diminished consciousness (Glasgow Coma Scale <10), an inadequate acoustic window, absence or insufficient quality of one of the MCA V signals, atrial fibrillation, significant carotid stenosis (>70%) or second stroke.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Relationship between spontaneous changes in arterial presure and cardiac output<br /><br>respectively in response to an oxygen pulse, and cerebral blood flow velocity<br /><br>and cortical oxygenation </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none</p><br>