Comparison of early vs late Plasma exchange in the treatment of acute weakness of limbs
Phase 3
- Conditions
- Health Condition 1: G373- Acute transverse myelitis in demyelinating disease of central nervous system
- Registration Number
- CTRI/2024/01/061209
- Lead Sponsor
- ICMR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patient having severe attack of myelitis.
2.MRC power in limb of grade = 2.
3.Patients meet the criteria of NMOSD.
Exclusion Criteria
Haemodynamic instability.
Coagulopathy.
Not giving consent for plasma exchange.
Severe or uncontrolled infection.
EDSS = 6 due to previous attack of NMOSD.
Patient refused to consent for the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the efficacy of simultaneous PLEX and IVMPS as compared to IVMPS with add on PLEX as treatment of severe attack of acute myelitis of NMOSD.Timepoint: Primary Outcome will be measured at three months of randomization.
- Secondary Outcome Measures
Name Time Method To determine the efficacy of simultaneous PLEX and IVMPS as compared to IVMPS with add on PLEX, one point improvement in EDSS will be categorised as clinically meaningful improvement.Timepoint: Secondary Outcome will be measured at one and six months of randomization.