The effect of an angiotensin receptor-neprilysin inhibitor to blood pressure and sympathoadrenal responses during mental arithmetic stress in patients with essential hypertensio

Not Applicable

Recruiting

• Conditions: essential hypertension

• Registration Number: JPRN-UMIN000051537
• Lead Sponsor: niversity of Toyama

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-07-06
• Last Update Posted: 17 October 2023
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

1) Patient under 20 years old or over 70 years old 2) Patient receiving angiotensin converting enzyme or within 36 hours of its discontinuation 3) Diabetic patient receiving aliskiren fumarate 4) Patient with severe hepatic impairment (Child-Pugh class C) 5) Pregnant woman or woman who may be pregnant 6) Patient judged by the research physician to be unsuitable for inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in blood pressure and indices of sympathoadrenal system (plasma catecholamines, power spectrum analysis obtained from heart rate variability measured by Holter ECG) during mental arithmetic stress before and after treatment (sacubitril-valsartan or valsartan administration)