Coping, Exposure, and Naltrexone Treatment With Alcoholics

National Institute on Alcohol Abuse and Alcoholism (NIAAA)1 site in 1 country160 target enrollmentNovember 3, 1999

ConditionsAlcoholism

Drugsnaltrexone (Revia)

Overview

Phase: Phase 4
Intervention: Not specified
Conditions: Alcoholism
Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Enrollment: 160
Locations: 1
Status: Completed
Last Updated: 20 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The study's purpose is to improve alcoholism treatment by investigating the combined effectiveness of a psychotherapy (Coping Skills Training and Cue Exposure Treatment - CSTCET) with naltrexone in a randomized clinical trial. Individuals will receive 2 weeks of CSTCET or a control treatment as inpatients followed by 12 consecutive weeks of receiving either naltrexone or placebo as outpatients. Followups at 24, 48, and 72 weeks after treatment is completed.

Registry

clinicaltrials.gov

Start Date

November 3, 1999

End Date

March 2000

Last Updated

20 years ago

Study Type

Interventional

Study Design

Factorial

Sex

All

Investigators

Sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Eligibility Criteria

Inclusion Criteria

•Meets criteria for alcohol dependence.

Exclusion Criteria

•Current diagnosis of dependence on other substances except nicotine.
•A history of psychosis or current psychotic symptoms.
•Current suicidality, homocidality, or psychiatric symptoms that require additional medication.
•Current use of disulfiram (Antabuse).
•Evidence of significant cerebral, renal, thyroid, or cardiac disease.
•History of opioid abuse in the previous year.
•History of cirrhosis, hepatocellular disease, or elevated bilirubin.
•Females who are pregnant, nursing, or not using a reliable method of birth control.