Efficacy Analysis of Complete Laparoscopic Resection of Recurrent Hepatocellular Carcinoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 主要终点
- Perioperative complications
研究概览
简要总结
This study is aiming to evaluate the clinical efficacy of complete laparoscopic resection of recurrent hepatocellular carcinoma (HCC).
详细描述
The investigators conducted a prospective study of 64 patients who were diagnosed with recurrent HCC and underwent surgical resection at the Sun Yat-sen University Cancer Center from June 2014 to November 2014; 31 patients were enrolled in the laparoscopic group and underwent complete laparoscopic resection of HCC, and 33 patients were enrolled in the control group and underwent open surgical resection. The operation time, intraoperative blood loss, shortest distance between the tumor edge and normal liver tissue, postoperative pain scores, postoperative time until the patient could walk, postoperative time until the patient could pass gas, hospital stay, and inpatient costs were compared between the two groups. The patients were followed up for one year after surgery, and the relapse-free survival was compared between the two groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •recurrent HCC after open surgery
- •recurrent HCC located in any part of the left lateral lobe or the diaphragm side of the right lobe and near the surface of the liver, which resulted in an easier operation
- •no significant surgical contraindications
- •no major vessel or bile duct tumor invasion and metastasis
- •grade A or B liver function or grade C liver function that recovered to grade A after liver-protective treatment;
- •the patient and his/her family was willing to undergo laparoscopic resection.
排除标准
- •major vessel or bile duct tumor invasion
- •recurrent HCC located in the right liver parenchyma and near secondary vessels and bile ducts, resulting in a difficult operation
- •grade C liver function
- •significant surgical contraindications
- •the patient and his/her family declined laparoscopic hepatectomy.
结局指标
主要结局
Perioperative complications
时间窗: within the first 30 days
The operation time, intraoperative blood loss, shortest distance between the tumor edge and normal liver tissue, postoperative pain scores, postoperative time until the patient could walk, postoperative time until the patient could pass gas, hospital stay, and inpatient costs were compared between the two groups.
次要结局
- relapse-free survival(1 year after surgery)
研究者
Zhongguo Zhou
Dr.
Sun Yat-sen University