The Role of Non-invasive Diffusion-weighted Imaging With MRCP in the Diagnosis of Neoplastic Biliary Obstruction
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Sensitivity of magnetic resonance cholangiopancreatography
研究概览
简要总结
This study aims to evaluate the diagnostic value of non-invasive diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting neoplastic biliary obstruction.
详细描述
Both surgeons and endoscopists value accurate approaches for identifying the source of biliary stricture in patients with obstructive jaundice. Cholangiocarcinoma or a benign stricture may cause a biliary stricture. Many imaging methods were used to diagnose the cause of biliary stricture.
Diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a non-invasive imaging modality that can potentially differentiate between malignant and benign biliary obstructions based on the measurement of water diffusion in tissues.
The gold standard of the research is endoscopic retrograde cholangiopancreatography (ERCP) and histology. Patients' diagnoses and follow-up were further verified by ERCP or histopathology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years) with clinically suspected biliary obstruction (e.g., jaundice, elevated liver enzymes, cholestasis).
- •Patients who are scheduled for magnetic resonance cholangiopancreatography (MRCP) and have undergone conventional imaging [ultrasound or computed tomography (CT)].
- •Patients who will undergo further invasive procedures, e.g., endoscopic retrograde cholangiopancreatography (ERCP), biopsy.
排除标准
- •Patients with contraindications to magnetic resonance imaging (MRI) (e.g., pacemakers, metal implants).
- •Patients who have previously undergone major biliary surgery or stent placement.
- •Pregnant or lactating women.
结局指标
主要结局
Sensitivity of magnetic resonance cholangiopancreatography
时间窗: Immediately after magnetic resonance cholangiopancreatography (Up to 1 hour)
Sensitivity of magnetic resonance cholangiopancreatography to predict of a tumor will be recorded.
次要结局
未报告次要终点
研究者
Hekmat Samir Baumey
Lecturer of Diagnostic Radiology, Damnhour National Medical Institute
The General Authority for Teaching Hospitals and Institutes