Comparison Between Incidence of Post Operative Sore Throat with Conventional Intubation and 180 Degree Rotation of Endotracheal Tube During Intubation in Adult Patient Under General Anaesthesia
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Incidence of postoperative sore throat assess by sore throat grading
研究概览
简要总结
GROUP C , patients intubated by conventional method of intubation.
GROUP R , patients intubated by 180 degree rotation of endotracheal tube during intubation.
After shifting the patient to the operating room, patient will be placed in supine position and
standard monitors will be attached including heart rate , electrocardiogram , non
invasive blood pressure monitor and pulse oximetry. Pre-oxygenation will be done
with 100 percent Oxygen for 3 minutes. Induction will be done with inj. midazolam 1mg, inj.
propofol 2 mg per kg , inj. fentanyl 2 mcg per kg, inj. vecuronium 0.1mg per kg intravenously.
Appropriate size of endotracheal tube will be chosen according to the age of the patient.
Patient will be placed in the supine position with the head in sniffing position to facilitate
optimal alignment of the oral pharyngeal and laryngeal axis. After achieving adequate depth of anaesthesia and ensuring jaw relaxation, the endotracheal tube inserted using MacIntosh
laryngoscope by conventional method and 180 degree clockwise rotation of endotracheal
tube when tip of endotracheal tube just enters in glottis. Correct positioning will be confirmed
by observing bilateral chest movement, five point auscultation of breath sounds and the
presence of a square wave capnography. The patient will be ventilated using oxygen plus nitrous
oxide or Air plus sevoflurane until MAC 0.8 to 1.2 is achieved. Further course of anaesthesia will
proceed as per standard protocols keeping in mind need of the patient, and surgery.
At the end of the surgery, neuromuscular blockade will be reversed using intravenous
neostigmine 0.05mg per kg and glycopyrrolate 0.01mg per kg. After confirming adequate reversal of
neuromuscular blockade and return of spontaneous respiration, the endotracheal tube will be
removed once the patient is awake, obeying verbal commands and able to maintain a patent
airway. The patient will be then shifted to the post op recovery room. In cases where
endotracheal tube removal is not performed due to clinical or surgical reasons, the patient
will be excluded from the study to maintain consistency in outcome assessment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)(—)
- 性别
- All
入选标准
- •ASA l-lll Patient undergoing general anaesthesia with an Endotracheal tube placement Age more than 18 years Ability to communicate pain in the postoperative period.
排除标准
- •Pre existing sore throat, upper respiratory tract infection or recent cold with in 2 weeks Pregnant women Surgery involving pharynx larynx and vocal cord More than one attempt of intubation History of lung disease Difficult airway.
结局指标
主要结局
Incidence of postoperative sore throat assess by sore throat grading
时间窗: At baseline
次要结局
- Severity of postoperative sore throat at different time intervals after extubation(Assessment of Hemodynamic parameters HR, SBP, DBP,MAP after intubation)
研究者
Kundan Kumar Jangir
ABVIMS and Dr RML Hospital New Delhi
