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Fractional FLOw Reserve In Cardiovascular DiseAses

Completed
Conditions
Coronary Artery Disease
Acute Coronary Syndrome
Registration Number
NCT04597489
Lead Sponsor
LinkCare GmbH
Brief Summary

The FLORIDA (Fractional FLOw Reserve In cardiovascular DiseAses) study sought to investigate outcomes of FFR-guided versus angiography-guided treatment strategies in a large, real-world cohort.

Detailed Description

The objective of the FLORIDA study was to investigate mortality outcomes of FFR-guided versus angiography-guided treatment strategies in a large, real-world patient cohort, including patients with different stages of coronary artery disease as well as patients with acute coronary syndrome (ACS). All patients were followed for a period of 3 years after the index date. The analysis period extended from the individual index date to the date of death or the end of the 3-year follow-up period. Patients were matched for sex, presence of acute coronary syndrome, age ± 5 years, and propensity scores estimated with logistic regression based on 72 variables , with each FFR patient matched to the closest angiography-only patient

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
64045
Inclusion Criteria
  • At least one inpatient coronary angiography for suspected coronary artery disease between January 2014 and December 2015.
Exclusion Criteria
  • Loss to follow-up of other reasons than death (i.e. change of insurance)

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
All-cause mortality36 months

All patients were followed for a period of 3 years after the index date. The analysis period extended from the individual index date to the date of death or the end of the 3-year follow-up period. The primary endpoint was mortality at 3 years, prospectively assessed at a quarterly basis.

Secondary Outcome Measures
NameTimeMethod
All-cause mortality24 months

Prospectively assessed at a quarterly basis.

Trial Locations

Locations (1)

LinkCare GmbH

🇩🇪

Stuttgart, Germany

LinkCare GmbH
🇩🇪Stuttgart, Germany

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