Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics
- Conditions
- Metabolomics; Retinopathy; Etiology
- Interventions
- Other: etiology
- Registration Number
- NCT06408571
- Lead Sponsor
- Zhongnan Hospital
- Brief Summary
Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was explored.
- Detailed Description
1. Clinical data of patients with RVO and DR Were retrospectively studied to analyze their pathogenesis. 2. Metabolomic studies were conducted on body fluids (intraocular fluid and peripheral blood) of patients with RVO and DR And control group to find out the differences and find new targets for the prevention and treatment of RVO and DR.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 3900
- Age ≥18 years old
- Confirmed diagnosis of retinal vein obstruction and diabetic retinopathy through ophthalmic specialist examination
- Severe systemic diseases
- Pregnant and lactating patients
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Experimental group etiology Patients with retinal vein obstruction and diabetic retinopathy
- Primary Outcome Measures
Name Time Method Screening of prognostic markers and model validation 1/12/2024-30/12/2024 1. Surface markers and key molecules related to the study of diseases were screened out, and a biomarker model for assessing disease prognosis was established.
2. Candidate differential molecules were screened through a training cohort, a Cox regression model was constructed, and the prognostic value of the model was verified in the test cohort.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Zhongnan Hospital of Wuhan University
🇨🇳Wuhan, Hubei, China