Incidence of Retinopathy and Associated Risk Factors in Children and Young Adults With Type 1 Diabetes in Denmark
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Odense University Hospital
- Enrollment
- 132
- Locations
- 1
- Primary Endpoint
- Incidence of diabetic retinopathy and proliferative diabetic retinopathy
Study Overview
Brief Summary
The objective of this study is to clarify the current diabetic status, including development of complications, in a nationwide cohort of type 1 diabetics, who were last examined together in a large study in 1995. These youngsters were originally participating in a nationwide study of children with type 1 diabetes in Denmark back in 1986. The investigators will try to establish risk factors for developing diabetic retinopathy. The investigators will have emphasis on retinal vessel geometry and the possibilities for early detection of reversible retinal changes, and prediction of other vascular complications.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 25 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Participation in the follow-up study in 1995
Exclusion Criteria
- •No retinal photographs from 1995
Outcomes
Primary Outcomes
Incidence of diabetic retinopathy and proliferative diabetic retinopathy
Time Frame: 16 years
Using the ETDRS grading protocol the degree of retinopathy in 2011 will be assessed by grading 7-field fundus photographs taken at follow-up examination. This will be related to the degree of retinopathy found in the patients in 1995, where the last study of the cohort took place.
Secondary Outcomes
- Vessel diameters as a predictor of diabetic retinopathy and proliferative diabetic retinopathy(16 years)
Investigators
Rebecca Broe Pedersen
MD
Odense University Hospital