NCT04614129已完成不适用
Lung Cancer Risk and Early Detection in Firefighters
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 734
- 试验地点
- 2
- 主要终点
- Nodule detection rate
研究概览
简要总结
This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •40-80 years of age or with 10 years of firefighting experience
- •Current or retired firefighters
- •No personal history of lung cancer
- •Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study
排除标准
- •Any active cancer (undergoing treatment or diagnosed within the past 5 years)
结局指标
主要结局
Nodule detection rate
时间窗: 12 months
Frequency of nodule detection
High-risk nodule detection rate
时间窗: 12 months
Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious
次要结局
- Coronary artery calcification (CAC) ordinal scores(12 months)
- Interstitial lung disease detection rate(12 months)
研究者
Erica T. Warner, ScD MPH
Associate Professor of Medicine
Massachusetts General Hospital
研究点 (2)
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