Exercise to Improve Brain Health in Older African Americans

Phase 2

Recruiting

• Conditions: Aging; Alzheimer Disease; Healthy Aging; Cognitive Change

• Registration Number: NCT05597124
• Lead Sponsor: Rutgers, The State University of New Jersey

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-10-24
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 280

Inclusion Criteria

Inclusion Criteria:<br><br> - self-identify as either African American or Black;<br><br> - be age 60 or older;<br><br> - able to speak, read, and understand English;<br><br> - available over the study period; independently ambulatory (i.e., not needing a<br> wheelchair, walker, or cane);<br><br> - meet criteria for low levels of physical activity (less than 60 minutes per week)<br> based on the International Physical Activity Questionnaire (IPAQ-short version);<br><br> - scoring 28-35 (inclusive) on the Telephone Interview for Cognitive Status Modified<br> (sensitivity [43%], specificity [94%] for lower threshold; sensitivity [93%],<br> specificity [42%] for upper threshold)55.<br><br> - scoring 20-26 (inclusive) on the Montreal Cognitive Assessment (MoCA) during the<br> in-person screening<br><br> - have clearance to participate from their primary care physician, with oversight of<br> all our patient health under the guidance of our physician-scientist Co-I, William<br> Hu, Chief of Cognitive Neurology at Rutgers.<br><br>Exclusion Criteria:<br><br> - color-blindness (because some of our tasks utilize color as a cue);<br><br> - any diagnosed neurological disorder (including headaches and peripheral neuropathy);<br> diagnosed or self-reported non-neurological conditions that likely affect MTL<br> outcomes, such as, major depressive disorder (or a Geriatric Depression Scale-Short<br> Form score = 5), schizophrenia, delusional disorder, schizoaffective disorder or<br> significant psychiatric symptoms that could impair the completion of the study<br> (e.g., psychosis), substance-related and addictive disorders (or treatment in past<br> five years), chemotherapy or radiation treatment for cancers, planning to undergo<br> general anesthesia during the study period;<br><br> - exercise contraindications, such as, orthopedic complications, myocardial<br> infarction, coronary artery bypass grafting, angioplasty or other cardiac condition<br> in the past year, current treatment for congestive heart failure, angina,<br> uncontrolled arrhythmia, deep vein thrombosis (DVT) or another cardiovascular event,<br> and uncontrolled hypertension with resting systolic or diastolic blood pressures ><br> 180/110 mmHg.

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Generalization Performance on the Concurrent Discrimination and Transfer Task;Generalization Performance on the Acquired Equivalence Task;Medial Temporal Lobe Neural Flexibility