NCT05772767已完成不适用
Control of Growth and Invasiveness of Glioblastoma by Modulation of Ciliogenesis in Glioma Stem Cells. A Novel Target Against Glioblastoma for Precision Medicine. RF-2019-12368786
Fondazione Policlinico Universitario Agostino Gemelli IRCCS2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2021年2月15日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Biological
研究概览
简要总结
The study aims at investigating the cilium-related transcriptome in patients-derived glioblastoma stem cells and the potential impact of modulation of cilium players in vitro, in vivo and ex vivo in glioblastoma brain organoids. Moreover, drugs inhibiting cilia disassembly will be tested. Finally, the potential prognostic role of a cilium-related gene expression signature in glioblastoma will be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •To be enrolled in the study patients must:
- •Have a radiological diagnosis of supratentorial glioblastoma, or
- •Have a radiological diagnosis of first recurrence of a primary supratentorial glioblastoma (for which a formal histopathologic diagnosis of glioblastoma had been made at first surgery), according with RANO criteria (Wen, 2010);
- •Be a candidate to neurosurgery for glioblastoma at the Operational Unit of Neurosurgery FPG;
- •Be of an age of 18 years or above;
- •Provide written informed consent for participation to the study.
- •Exclusion criteria
- •To be enrolled in the study patients must not:
- •Have not enough pathological material removed at surgery available both for mandatory routine histopathological diagnosis and for the present study, as judged by the Principal Investigator;
- •Have not a definitive pathological diagnosis of a primary supratentorial GBM, according with 2016 WHO classification.
排除标准
- 未提供
结局指标
主要结局
Biological
时间窗: Through study completion, an average of 2 years
Correlation between modulation of cilia disassembly complex genes, and tumor growth and invasion in brain organoids.
次要结局
未报告次要终点
研究者
研究点 (2)
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