Healthgrain WP 4.4.3: Effects of Whole Grain on Weight Maintenance/Weight Reduction in Overweight Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Body weight and composition
研究概览
简要总结
The aim of this study is to investigate the potential beneficial effect of wholegrain on body weight and composition as well as cardiovascular risk in overweight women.
详细描述
Objective
To study the effect of the 'wholegrain concept', i.e. high intake of wheat wholegrain (WW) vs. refined wheat (RW) grain products on body weight and composition.
Design: In this open-labeled randomized trial, 72 postmenopausal women with metabolic syndrome features were prescribed a mild calorie-restricted diet with a deficit of ~1,250kJ/d. Following 2 weeks run-in period on RW products, they were randomized to 12 weeks intervention with RW or WW products providing 2,000kJ/d.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI 27-37
- •Postmenopausal (>1y) women
- •40-70 years old
排除标准
- •Medication (hypertensive treatment not included)
- •BP > 160/100
- •Fasting glucose > 7mM
- •Fasting cholesterol > 6.5mM
- •Known chronic illnesses
研究组 & 干预措施
WW
wholegrain wheat
干预措施: wholegrain (Other)
RW
refined wheat
干预措施: refined wheat (Other)
结局指标
主要结局
Body weight and composition
时间窗: 0, 6 and 12 wks
次要结局
- Cardiovascular risk markers(0, 6 and 12 wks)
- Fecal parameters(0 and 12 wks)