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临床试验/NCT07137286
NCT07137286招募中不适用

Genetic Influence on LDL Hyper-responsiveness in Patients Following a Ketogenic Diet

Mayo Clinic1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2025年9月11日最近更新:
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适应症

试验速览

阶段
不适用
状态
招募中
发起方
Mayo Clinic
入组人数
100
试验地点
1
主要终点
Number of Patients to have a genetic mutation
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to identify whether individuals following a ketogenic diet who experience extreme LDL-C elevation, termed "hyper-responders", have identifiable genetic variations in genes involved in cholesterol absorption.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —（Adult, Older Adult）
性别
All
接受健康志愿者
否

入选标准

  • •18 years of age or older
  • •LDL-C >170 mg/dL in response to starting a ketogenic diet

排除标准

  • •Patients who do not consent to blood draw for genetic testing
  • •Those with LDL-C <170 mg/dL on a ketogenic diet

结局指标

主要结局

Number of Patients to have a genetic mutation

时间窗: Baseline

Genetic Mutation will be defined as a mutation in ABCG5, ABCG8, APOB, APOE, CETP, CYP27A1, LDLR, LDLRAP1, LIPA, LPL, LRP6, and PCSK9 genes

次要结局

未报告次要终点

研究者

发起方
Mayo Clinic
申办方类型
Other
责任方
Principal Investigator
主要研究者

Stephen L. Kopecky

Principal Investigator

Mayo Clinic

研究点 (1)

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