Effect of Sleep Apnea on Blood Pressure Control and Outcome Early After Subarachnoid Hemorrhage
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Time to blood pressure target
研究概览
简要总结
In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.
详细描述
Patients admitted with non-traumatic SAH will be consented and screened for sleep apnea within 48 hours after hospital admission. Blood pressure and clinical outcome will be monitored throughout ICU treatment and hospital stay, respectively. Diagnosis of sleep apnea will be confirmed on follow-up 3-6 month after SAH by sleep apnea screening (portable cardiorespiratory monitoring and out-of-center polysomnography, respectively).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subarachnoid Hemorrhage (Hunt & Hess 1 to 4)
- •> 18 years of age
- •Ability to consent for study of healthcare proxy able to confirm patient will to participate
排除标准
- •Stoke within 3 month prior to admission
- •Intubation prior or within 24 hours after admission
- •no healthcare proxy
结局指标
主要结局
Time to blood pressure target
时间窗: Within 10 Days of hospital admission with subarachnoid hemorrhage
The time required to reach blood pressure target as defined by care provider.
Medication needed to achieve blood pressure target
时间窗: Within 10 Days of hospital admission with subarachnoid hemorrhage
Blood pressure medication required to reach blood pressure target as defined by care provider.
次要结局
- Change in modified ranking scale (mRS) from baseline to discharge and follow-up visit, respectively.(3 to 6 Month after SAH)
- Change in NIH stroke scale score (NIHSS) from admission to discharge and follow-up visit, respectively.(3 to 6 Month after SAH)
- Barthel Index at discharge at follow-up visit, respectively.(3 to 6 Month after SAH)
研究者
Sebastian Zaremba
Physician
University Hospital, Bonn