Effect Of Glucagon on Treatment Of Acute Severe Asthma Attack
Phase 3
Recruiting
- Conditions
- Asthma.Asthma
- Registration Number
- IRCT20131118015446N13
- Lead Sponsor
- Ahvaz Jundishapur University Of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Severe asthma attack
Age between 18 and 55
Exclusion Criteria
History of diabetes mellitus
Smoking
Ischemic heart disease
Emphysema or chronic bronchitis
Insulinoma
pheochromocytoma
Current oral or injectable corticosteroids, pregnancy
Pregnancy
Lactation
Need for intubation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Peak Expiratory Flow Rate (PEFR). Timepoint: At 0, 10, 15, 30, 45 ,60 minutes after intervention. Method of measurement: Litre/minute, by spirometry.;FEV1. Timepoint: At 0, 10, 15, 30, 45 ,60 minutes after intervention. Method of measurement: Litre, by spirometry.
- Secondary Outcome Measures
Name Time Method Respiratory rate. Timepoint: At 0 and 60 minutes after intervention. Method of measurement: Counting of respiration in one minute.;Pulse rate. Timepoint: At 0 and 60 minutes after intervention. Method of measurement: Counting of pulse in one minute.;Blood pressure. Timepoint: At 0 and 60 minutes after intervention. Method of measurement: mmHg, by sphygmomanometer.;Blood glucose. Timepoint: At 0 and 20 minutes after intervention. Method of measurement: mg/dL, by glucometer.;Blood oxygen saturation levels (SpO2). Timepoint: At 0 and 60 minutes after intervention. Method of measurement: Percentage, by pulse oximeter.
Related Research Topics
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What molecular mechanisms mediate glucagon's bronchodilatory effects in acute severe asthma?
How does intravenous glucagon compare to beta-agonists in improving FEV1 and peak expiratory flow during asthma exacerbations?
Which inflammatory biomarkers correlate with glucagon response in phase III interventional asthma trials?
What adverse events are associated with glucagon infusion in asthma patients and how are they managed?
Are glucagon receptor agonists being evaluated as combination therapies with corticosteroids for refractory asthma attacks?