Reduction of emergence reactions like cough, hypertension after general anaesthesia with intratracheal lignocaine as compared to intratracheal normal saline in endoscopic transsphenoidal pituitary surgery patients

Phase 1/2

Recruiting

• Conditions: Patients undergoing endoscopic trans sphenoidal pituitary surgery

• Registration Number: CTRI/2018/04/013011
• Lead Sponsor: All India Institute of Medical Sciences AIIMS New Delhi

Brief Summary

In this study we will be instilling 2% lignocaine 0.05ml in group L and Normal saline 0.05ml in group NS , 5 minutes before extubation in patients who underwent endoscopic transphenoidal surgery.This type of study have never been done in endoscopic trans sphenoidal surgery patients. We will be determinining the effect of lignocaine in suppressing the cough during emergence from anaesthesia. Preventing cough in this patients is important in these patients to prevent the increase in intracranial pressure post surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-02
• Last Update Posted: 2018-03-30

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients between 18 – 65 years of age.
• ASA grade I & II patients.
• Patients of Pituitary tumor posted for elective endoscopic transphenoidal surgery for tumor excision.

Exclusion Criteria

• Refusal of consent 2.
• Patients with history of smoking or chronic cough 3.
• Patients with history of upper respiratory tract infection (URI) in last 8 weeks 4.
• Patients with bleeding disorders 5.
• Previous laryngeal or tracheal surgery or pathology 6.
• Patients with history of gastric reflux 7.
• Patients with pulmonary disease, renal, cardiac or hepatic disorders, uncontrolled diabetes 9.
• Patients with clinical sign of hypothyroidism 10.
• Patients with BMI > 35kg/mt2 11.
• Patients with the history of hypertension (controlled or uncontrolled) 12.
• Patients with upper respiratory tract infection 13.
• Patients having history of allergic reactions to study drug Post inclusion exclusion : 1.
• Need of more than 2 attempts of tracheal intubation or need of bougie for tracheal intubation 2.
• Patients who can not be extubated and are planned for elective ventilation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the effect of intratracheal lidocaine on suppressing the cough on emergence from general anesthesia in patients undergoing endoscopic transphenoidal pituitary surgery.	During emergence from general anesthesia after the end of the surgery

Secondary Outcome Measures

Name	Time	Method
To determine effect of intratracheal lignocaine on HR and BP changes	To determine the effect of intratracheal lignocaine on the emergence time, extubation time and recovery time

Trial Locations

Locations (1)

All India Institute of Medical Sciences; 🇮🇳 Delhi, DELHI, India

All India Institute of Medical Sciences

🇮🇳Delhi, DELHI, India

Ruhi Mamualiya

Principal investigator

7838823890

ruhimamualiya@gmail.com