A Retrospective Multicenter Real-World Evidence Study of Open, Laparoscopic and Robotic-assisted Staging Surgery for Endometrial Cancer

From a treatment standpoint, multidisciplinary, multimodality treatment is indicated for the management of endometrial cancer. For Endometrial cancer cases suitable for surgery (irrespective of stage), Total hysterectomy with Bilateral salpingo-oophorectomy (TH/BSO) with surgical staging is offered. Adjuvant radiation (brachytherapy/EBRT) with/without systemic therapy is offered, depending on patients and disease factors. In patients not suitable for surgery, radiation and/or systemic therapy are offered. Patients are then re-evaluated for surgical resection. While offering surgical treatment to patients with Stages I, II, and III endometrial cancer, the selection of technique (open, laparoscopic, or robotic-assisted) is an important discussion point amongst the surgical team as well as with the patient. Leading guidelines advocate TH/BSO and lymph node assessment may be performed by any surgical route (eg, laparoscopic, robotic, vaginal, abdominal. Although these guidelines recommend a minimally invasive approach as the standard in uterine-confined disease due to a lower rate of surgical site infection, transfusion, venous thromboembolism, decreased hospital stay, and lower cost of care, without compromise in oncologic outcomes. There is a large body of global published literature with respect to the techniques of surgery for endometrial cancer. However, the majority of evidence emanates from the Western world, and there is a paucity of evidence in Indian settings. We could not find any multi-centric study from India for any of these techniques (single arm or multiple cohorts). To fill this gap, there is a need for a multi-centric real-world evidence study from India that can serve as a local benchmark for perioperative, oncological, and functional outcomes for staging surgery for endometrial cancer.