Clinical trial to evaluate the effect of vitamin D supplementation on discogenic pain and sensory deficits associated with cases afflicted with lumbar disc herniation

Vice Chancellor for Research Shiraz University of Medical Sciences0 个研究点目标入组 380 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

暂无简介。

•Inclusion Criteria:
•1) No coexistent or preexisting spine pathology (e.g. Spondylolisis, Spondylolisthesis, Infection, Tumors, Fracture);
•2) Single level lumbar disc herniation;
•3) Discogenic pain duration from onset up physician evaluation: less than 8 weeks;
•4) Compliance with study protocol;
•5) Normal Lab studies;

•1) Daily supplementation intake of more than 800 IU of vitamin D;
•2) Serum calcium level more than 10.5 md/dl;
•3) Hypercalciuria ( spot urine calcium creatinin ratio more than 0.4);
•4) Lymphoma, Sarcoidosis, TB, Hyperparathyroidism, Celiac disease, malabsorption syndromes;
•5) Hx of renal stone;
•6) Hx of inflammatory back pain;
•7) Impaired renal function tests (GFR less than 30);
•8) Impaired hepatic function tests;
•9) Abnormal Serum Phosphorus, Alkaline phosphatase and Parathyroid hormone values;
•10) FBS more than 126;
•11) Previous spine surgery;
•12) Hx of trauma;
•13) Taking Anticonvulsant, Anti-TB medications or vitamin D analogs;
•14) Cauda Equina syndrome that requires emergency surgical decompression.

发起方

Vice Chancellor for Research Shiraz University of Medical Sciences