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Clinical Trials/NCT07566858
NCT07566858Not yet recruitingNot Applicable

Comparing Clinical Scores, Biomarkers, and CT Findings in Patients With Acute Pulmonary Embolism Across Different Hospital Departments

Sohag University0 sites50 target enrollmentStarted: May 1, 2026Last updated:

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
50

Study Overview

Brief Summary

This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments.

The study will include patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Clinical data, laboratory results, and imaging findings will be collected and analyzed to evaluate their diagnostic and prognostic value.

The goal of this research is to identify the most reliable and practical tools for early diagnosis and risk stratification of acute pulmonary embolism, which may help improve patient management and outcomes.

This is an observational study and does not involve any intervention or change in standard patient care.

Detailed Description

This study is an observational analytical study designed to evaluate and compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients presenting with acute pulmonary embolism (PE) across different hospital departments at Sohag University Hospital.

Acute pulmonary embolism is a potentially life-threatening condition that requires prompt diagnosis and risk stratification. Various clinical scores (such as Wells score and Geneva score), along with laboratory biomarkers (such as D-dimer and others), and imaging modalities (especially CT pulmonary angiography), are commonly used in the diagnostic and assessment process.

The study aims to assess the diagnostic accuracy and clinical usefulness of these parameters, individually and in combination, in patients with confirmed acute pulmonary embolism.

Data will be collected retrospectively and/or prospectively from patient records and clinical assessments. Variables will include demographic data, clinical presentation, risk factors, laboratory investigations, clinical scoring systems, and radiological findings.

The study will compare these parameters across different hospital departments to determine variations in presentation and diagnostic approaches, as well as to evaluate the best predictive indicators for disease severity and outcomes.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • • Adults aged ≥ 18 years
  • Confirmed acute pulmonary embolism by CTPA

Exclusion Criteria

  • • Chronic pulmonary embolism
  • Non-diagnostic CTPA
  • Refusal to participate
  • Severe renal impairment precluding contrast-enhanced CT
  • Known hypersensitivity to contrast media

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Esraa Elbadry Elrabie

Resident of Chest Diseases

Sohag University

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