Simplified Algorithm for the Prevention of Postoperative Nausea and Vomiting in an Oncological Hospital
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 270
- 试验地点
- 1
- 主要终点
- postoperative nausea and vomiting
研究概览
简要总结
Previous history of nausea and vomiting induced by prior chemotherapy still not included as predictive factor of postoperative nausea and vomiting, although has been demonstrated that has influence in postoperative outcome.
The project aims to evaluate the efficacy of a simplified algorithm in prevention postoperative nausea and vomiting , with pacients with previous history of nausea and vomiting induced by prior chemotherapy, submitted to medium or large surgery.
详细描述
Quasi-experimental study, with evaluation after the application of a specific postoperative nausea and vomiting prevention algorithm for cancer patients.
The study will be carried out in 2 phases:
Phase 1: Team training. In this phase, a protocol was established for PONV prophylaxis, using two questions:
- Patient undergoing chemotherapy before surgery;
- Patient presented chemotherapy induced nausea and vomiting (CINV).
If the answer is yes to both questions, the anesthetist administers 3 antiemetics (4mg dexametasone, 4mg ondansetron and 0,625mg droperidol). If the answer is no to one of the questions, the anesthetist administers 2 antiemetics (4mg dexametasone and 4mg ondansetron); In this phase, educational measures will be implemented by team meetings and individual approach of all anesthesiologists at ICESP to present the study project and the algorithm. A summary of the the study will be sent daily through the social network Whats App®.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
盲法说明
The patient didn't know if he received the third anti emetic
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients who underwent medium to large surgery
排除标准
- •Patients who are unable to communicate (orotracheal intubation after the surgery, confusion or agitation) or understand the Portuguese language;
- •Insulin dependent patients
- •Patients who underwent emergency surgery and neurosurgery
- •Pacients who had an increased QT interval on the electrocardiogram
- •History of allergy to dexametasone, ondansetron or droperidol
- •Refusal to participate
研究组 & 干预措施
Patients with previous CINV
Patients who had previous nausea and vomiting induced by chemoterapy.
干预措施: Droperidol (Drug)
结局指标
主要结局
postoperative nausea and vomiting
时间窗: from 0 to 24 postoperative hours
record of any episode of nausea and or vomiting in the 24 postoperative hours
次要结局
- Changing in the institutional protocol(from the begining to the study to the end of the study (2 years))