Clopidogrel Efficacy and Acute Coronary Syndromes

Completed

• Conditions: Acute Myocardial Infarction

• Registration Number: NCT00839267
• Lead Sponsor: Charles University, Czech Republic

Brief Summary

The purpose of this study is to compare clopidogrel effectiveness between severe hemodynamically unstable versus stable patients with acute myocardial infarction.

Detailed Description

Clopidogrel exists in oral form only. As a prodrug, it has to be metabolized to the active form by cytochrome system in the liver. Both facts could lead to lower efficacy of the drug in hemodynamically unstable patients, where splanchnic and liver hypoperfusion is present. We hypothesised that clopidogrel efficacy is insufficient in patients with acute myocardial infarction and severe hemodynamic instability. Therefore we would like to compare the effect of clopidogrel in unstable STEMI patients on mechanical ventilation with stable STEMI patients.

Study Timeline

• Study Start: 2006-06
• Study Completion: 2008-12
• Status Verified: 2009-02
• Study First Submitted: 2009-02-06
• Study First Submitted QC: 2009-02-06
• Study First Posted: 2009-02-09
• Last Update Submitted: 2009-02-09
• Last Update Posted: 2009-02-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lower efficacy of clopidogrel determined by VASP measurement	6 months

Secondary Outcome Measures

Name	Time	Method
Higher frequency of stent thrombosis in the unstable group	6 months

Trial Locations

Locations (1)

Cardiocenter, 3rd Medical School, Charles University and University Hospital Kralovske Vinohrady; 🇨🇿 Prague, Czech Republic