Tension-Type Headache Gene Expression and Methylation
- Conditions
- Tension-Type Headache, Unspecified, Intractable
- Registration Number
- NCT06562855
- Lead Sponsor
- University of Gaziantep
- Brief Summary
Tension-type headache (TTH) refers to pain radiating from the forehead to the back of the head as a bilateral band. It often occurs without warning and spreads to the neck muscles. Patients describe it as tension, pressure, or dull pain. It is usually triggered by stress. The complexity of the processes is the biggest difficulty in diagnosing and treating TTH. Although there are genetic connections, there are no single responsible genes.
- Detailed Description
130 TTH patients and 117 healthy controls were included in the study. Serum markers of the patients were measured. WNT5A, responsible for the Wnt-B catenin signaling pathway, and its receptor FZD3 were examined in the pathogenesis of TTH. Expression changes and methylation profiles of genes were obtained. Genetic and serum parameters were compared. Diagnostic powers were determined by ROC analyses.
Recruitment & Eligibility
- Status
- AVAILABLE
- Sex
- All
- Target Recruitment
- Not specified
- (ICHD)-3 criteria
- Male and female
- 17-82 years
- not diagnosed with tension-type or other primary headaches
- Tension-type headache not diagnosed
- below 16 ages
- pregnant woman
- subdural hematoma
- intracranial mass
Study & Design
- Study Type
- EXPANDED_ACCESS
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Medicine
🇹🇷Gaziantep, Şehitkamil, Turkey
Gaziantep University Şahinbey Research and Application Hospital
🇹🇷Gaziantep, Şehitkamil, Turkey