Effective treatment of adolescents with aggression problems in clinical and non clinical settings

Completed

Conditions: Aggressive behaviour among adolescents with externalising behaviour problems DSM-IV: Conduct disorder (314.9)
Disruptive behavior disorder not otherwise specified (312.9) Intermittent explosive disorder (312.34)
Oppositional defiant disorder (313.81)
10037173
10024136

Registration Number: NL-OMON36647

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 168

Inclusion Criteria

-Full scale IQ >= 80 ; PIQ >= 75 en VIQ >= 80.
-Minimal score on MOAS of 5 on both initial screenings
-Age lies between 12 and 18 years
-(Psychiatric) Medication free at beginning of the screening procedure.
-Minimal motivation among participant and family
-Reading level of Avi 6 or 7.
-Clinical diagnosis of 'Oppositional defiant disorder' or 'Conduct disorder'

Exclusion Criteria

- Previous ART or Risperidone (6 months)
- Psychotic condition
- Severe depression
- Severe substance dependency
- Suicidal tendencies
- Pregnancy or lactation
- Major medical problems
- Epilepsy
- Cardiovascular diseases
- Regular medication which strongly interacts with Risperidone
- Unable to sign informed consent

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>A % decrease in severity and frequency of aggressive behaviour as observed on<br /><br>the Modified Overt Aggression scale, completed by at least two different<br /><br>informants at baseline and after the intervention period (including follow up<br /><br>measurements after three and six months. A decrease of 40% counts as a response<br /><br>to treatment, between 20-30% decrease as a partial response and a decrease<br /><br>below 20% as a non response.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We aim to compare the profiles of treatment responders, non-responders and drop<br /><br>outs in relation to across various contexts (schools, centre for<br /><br>Orthopsychiatry and residential youth care agency). Our main question of<br /><br>enquiry here is: what profiles regarding aggressive behaviour and correlates<br /><br>relating to aggressive behaviour can be found among responders and non<br /><br>responders?<br /><br>It is hypothesised that non responder profiles to both treatment conditions<br /><br>show lower moral reasoning levels, higher levels of impulsiveness, pro active<br /><br>aggression, cognitive distortions relating to aggressive behaviour and<br /><br>delinquency and higher levels of callous unemotional traits at baseline.</p><br>