Effect of Injection Pentoxifylline on Liver Regrowth in the Liver Donor after Right Side Liver Removal for Liver Donor surgery for living donor Liver Transplant

Phase 3

Not yet recruiting

• Conditions: Liver donor,

• Registration Number: CTRI/2025/06/089632
• Lead Sponsor: Institute of Liver and Biliary Sciences

Brief Summary

Posthepatectomy liver failure (PHLF) remains a significant life-threatening problem after major hepatectomies. Pentoxifylline is shown to have potent vasodilating properties for peripheral blood vessels, along with the hepatic vasculature. In a Double-blinded, randomized, controlled trial (RCT) at a single tertiary care center (2006–2009) by Petrowsky, Henrik et al (Annals of Surgery, November 2010) on 101 Non-cirrhotic patients undergoing major Hepatectomy, they demonstrated beneficial effects of Pentoxifylline on regeneration of small remnant livers (RLBW ratio less than 1.2 percent). In mice model, pentoxifylline (Tian, Yinghua, et al Proceedings of the National Academy of Sciences 103.12 (2006)) is shown to confer protective effects against small-for-size syndrome in arterialized small-for-size liver transplantation. This Randomised control trial is being conducted to analyze the effect of Pentoxifylline supplementation in live donors undergoing donor hepatectomy with respect to markers of anatomical regeneration in a high volume liver transplant center in India.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-06-07
• Last Update Posted: 2025-10-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

All Voluntary Healthy Liver Donors undergoing Right Lobe Donor Hepatectomy.

Exclusion Criteria

Negative consent Hypersensitivity to pentoxifylline.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess effect of Pentoxifylline supplementation on Anatomical (Volume) Regeneration of liver in the Perioperative period (POD-14) in Right lobe donor Hepatectomy	On Post-operative Day-14

Secondary Outcome Measures

Name	Time	Method
To study the effect of Pentoxifylline supplementation on post-operative complications in donor right hepatectomy	Discharge from hospital
To evaluate the effect of Pentoxifylline on Liver function Tests- Time to Normalization	Baseline, POD- 1 to 7 and POD 14
To evaluate the effect of Pentoxifylline on biomarkers of liver regeneration (HGF, TNF-alpha, IL-6, TGF Beta, AFP)	Baseline, POD-3 and POD-7

Trial Locations

Locations (1)

Institute of liver and biliary Sciences; 🇮🇳 West, DELHI, India

Institute of liver and biliary Sciences

🇮🇳West, DELHI, India

Parneet

Principal investigator

7888524159

parneet.sunam@gmail.com