Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin
- Conditions
- Brain Metastases, Adult
- Interventions
- Other: Silibinin
- Registration Number
- NCT05793489
- Lead Sponsor
- Istituto Clinico Humanitas
- Brief Summary
The occurrence of brain metastases (BMs) is increasing given the availability of a more accurate radiological imaging such as MRI for detecting also small brain lesions and the most effective systemic therapy able to control extracranial disease. Although, the new target therapy and immunotherapy has proven to be effective on brain metastasis too, a subgroup of patients shows prove themselves unresponsive to medical treatment. A further subgroup of patients exhibit diffuse brain disease for the presence of multiple brain lesion (\>10 BMs) or leptomeningeal carcinomatosis. Among these patients the most treatment employed is represented by whole brain RT. Since the 1950s, whole-brain radiation therapy (WBRT) has been the most widely used treatment for patients with multiple brain metastases, given its effectiveness in palliation, widespread availability, and ease to delivery. However, the median overall survival recorded is restricted to 3 months, on the average. A better understanding of the molecular and cellular mechanisms underlying brain metastasis might be expected to lead to improvements in the overall survival rate for these patients. Recent studies have revealed complex interactions between metastatic cancer cells and their microenvironment in the brain. Priego et al. describe that brain metastatic cells induce and maintain the co-option of a pro-metastatic program driven by signal transducer and activator of transcription 3 (STAT3) in a subpopulation of reactive astrocytes surrounding metastatic lesions. In patients, active STAT3 in reactive astrocytes correlates with reduced survival from diagnosis of intracranial metastases. Blocking STAT3 signaling in reactive astrocytes reduces experimental brain metastasis from different primary tumor sources, even at advanced stages of colonization. Silibinin (or silybin) is a natural polyphenolic flavonoid isolated from seed extracts of the herb milk thistle (Silybum marianum). Silibinin has been shown to impair STAT3 activation. Preclinical studies show that Silibinin has an anticancer effects in vitro and in vivo.
Based on this background, the investigators designed a double arm randomized trial evaluating the benefit of Silibinin (in the form of marketed supplement) associated to WBRT respect to WBRT alone.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 44
- Age >18 years
- Histological or cytological confirmation of solid tumor malignancy
- Clinical indication for whole brain radiotherapy
- Karnofsky performance status (KPS) ≥60
- Written informed consent
- Prior WBRT
- KPS < 60
- Diagnosis of Lymphoproliferative disease
- Pregnant women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description WBRT + Silibinin Silibinin Patients undergo WBRT concomitant to Silibinin
- Primary Outcome Measures
Name Time Method Overall Survival 12 months Outcome will be evaluated in months
- Secondary Outcome Measures
Name Time Method Toxicity in term of use of corticosteroid therapy 12 months Outcome will be evaluated in term of use or not of corticosteroids
Brain Distant Failure (BDF) 12 months Outcome will be evaluated in months
Progression Free Survival (PFS) 12 months Outcome will be evaluated in months
Trial Locations
- Locations (1)
IRCCS Humanitas Research Hospital
🇮🇹Rozzano, Milano, Italy