Oral Mucosal Decontamination With Chlorhexidine for Prevention of Ventilator Associated Pneumonia in Children - A Randomized Controlled Trial
Overview
- Phase
- Phase 3
- Intervention
- Chlorhexidine gel
- Conditions
- Ventilator Associated Pneumonia
- Sponsor
- All India Institute of Medical Sciences, New Delhi
- Enrollment
- 86
- Locations
- 1
- Primary Endpoint
- Occurrence of ventilator associated pneumonia as defined by CDC diagnostic criteria
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to determine if oral mucosal application of chlorhexidine gel will prevent the development of ventilator associated pneumonia in children.
Detailed Description
Ventilator associated pneumonia as the name suggests refers to pneumonia occurring in the setting of mechanical ventilation. It accounts of 86% of nosocomial pneumonia and in contrast to other more common nosocomial infections is accompanied by a mortality rate of upto 76% in certain settings. A number of preventive methods have been studied to reduce the rate of VAP but a consensus is lacking with regards to appropriate preventive strategies. Studies in adults have shown a beneficial effect of oral mucosal application of chlorhexidine but similar studies in pediatric population are not available. This research project aims at addressing the gap.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Arms & Interventions
1
Chlorhexidine gel
Intervention: Chlorhexidine gel
2
Placebo gel
Intervention: Placebo gel
Outcomes
Primary Outcomes
Occurrence of ventilator associated pneumonia as defined by CDC diagnostic criteria
Time Frame: 21 days
Secondary Outcomes
- Antibiotic sensitivity of organism cultured(21 days)
- Duration of hospital stay(21 days)
- Duration of ICU stay(21 days)
- In hospital mortality rate(21 days)