Clinico-radiological Correlation of MRI Findings in Patients With Temporomandibular Joint Disc Perforation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 282
- 试验地点
- 1
- 主要终点
- Presence of TMJ Disc Perforation
研究概览
简要总结
To evaluate the presence of TMJ disc perforation on MRI and investigate its associations with internal disc derangements, disc configuration, condylar bone marrow signal patterns, joint effusion, and demographic or clinical variables such as age, sex, dental status, and pain severity.
详细描述
This study will prospectively evaluate temporomandibular joint (TMJ) disc perforation using magnetic resonance imaging (MRI) in a diverse adult population. The investigation will focus on identifying the prevalence of disc perforation and examining its relationship with key TMJ structural and functional parameters. Specifically, the study will assess internal disc derangements, variations in disc morphology, condylar bone marrow signal characteristics, and the presence of joint effusion. In addition, demographic and clinical factors-including age, sex, dental status, and pain severity-will be analyzed to determine their potential association with disc perforation.
MRI-based assessments will be performed using standardized imaging protocols, and all findings will be systematically recorded and evaluated. By integrating radiologic and clinical data, the study aims to improve the understanding of factors contributing to TMJ disc perforation and to support future diagnostic and therapeutic strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 14 Years 至 79 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with available temporomandibular joint (TMJ) MRI scans (both open- and closed-mouth)
- •Age ≥14 years
- •Complete clinical records including Visual Analogue Scale (VAS) pain scores and dental status
- •Willingness to participate in the study and provide informed consent (for prospective studies)
排除标准
- •Presence of systemic disorders affecting bone metabolism, including rheumatoid arthritis, chronic systemic corticosteroid therapy, Paget's disease, hypo- or hyperparathyroidism, osteomalacia, or renal osteodystrophy
- •History of medications that could alter bone architecture
- •Current orthodontic treatment
- •History of head and neck trauma or surgery
- •Presence of head and neck cystic or tumoral pathology
- •Prior radiotherapy or chemotherapy
- •Pregnancy
- •Presence of ferromagnetic objects in the head (contraindication to MRI)
结局指标
主要结局
Presence of TMJ Disc Perforation
时间窗: At MRI assessment (baseline, single time point)
Dichotomous outcome (Yes/No) indicating the presence of temporomandibular joint disc perforation, determined from closed- and open-mouth MRI images assessed by an experienced radiologist/oral and maxillofacial surgeon. Unit of Measure: Percentage of joints with MRI-confirmed disc perforation
次要结局
- Disc Configuration Distribution(At MRI assessment (baseline))
- Disc Position (Closed/Open-mouth)(At MRI assessment (baseline))
- Condylar Bone Marrow Signal Pattern(At MRI assessment (baseline))
- Joint Effusion Grade(At MRI assessment (baseline))
- Pain Severity (VAS per TMJ)(At clinical assessment coincident with MRI (baseline): retrospective clinical data)
- Dental Status(At clinical assessment (baseline): retrospective clinical data)
研究者
DİLARA NİL GÜNAÇAR
Assoc. Prof.
Recep Tayyip Erdogan University Training and Research Hospital