Improving Cardiac Secondary Prevention

Not Applicable

Active, not recruiting

• Conditions: Myocardial Infarction; Secondary Prevention
• Interventions: Behavioral: Education regarding telomere length

• Registration Number: NCT03269708
• Lead Sponsor: Western University, Canada

Brief Summary

The purpose of this study is to determine whether providing individuals with personalized information on cellular aging, including telomere length, will stimulate them to adhere to cardiac prevention strategies and improve exercise capacity.

Detailed Description

Individuals who have sustained a heart attack are at considerable risk for future cardiac events. A cardiac rehabilitation and exercise program can reduce this risk but it remains a challenge to adopt optimum lifestyle changes. We will determine whether providing individuals with information on leukocyte telomere length, will motivate them to improve their exercise performance. We will test whether professionally conveying this information will stimulate an individual to adhere to proven cardiac prevention strategies, looking at the extent to which one's exercise capacity improves over time.

Study Timeline

• Study First Submitted: 2017-08-30
• Study First Submitted QC: 2017-08-30
• Study First Posted: 2017-09-01
• Study Start: 2019-03-01
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-03
• Last Update Posted: 2024-05-07
• Primary Completion: 2024-09
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

1. Individuals who have sustained a myocardial infarction and entered the cardiac rehabilitation program

Exclusion Criteria

1. Individuals with genetic mutations that affect telomere length
2. Individuals who may not have the mental capacity to understanding the ramifications of risk biomarkers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Knowledge transfer group	Education regarding telomere length	Participants receive standard care in cardiac rehabilitation program plus education regarding telomere length

Primary Outcome Measures

Name	Time	Method
Exercise capacity based on cardiopulmonary exercise testing	after 6-month cardiac rehabilitation program	Online VO2 maximum

Secondary Outcome Measures

Name	Time	Method
Adherence to supervised exercise sessions	6 months	Proportion of prescribed supervised on-site exercise sessions attended
Activity assessment	6 months	Garmin recording

Trial Locations

Locations (1)

London Health Sciences Centre, Western University; 🇨🇦 London, Ontario, Canada