Improving Cardiac Secondary Prevention Through Personalized Biomarker Knowledge
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Myocardial Infarction
- Sponsor
- Western University, Canada
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Exercise capacity based on cardiopulmonary exercise testing
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The purpose of this study is to determine whether providing individuals with personalized information on cellular aging, including telomere length, will stimulate them to adhere to cardiac prevention strategies and improve exercise capacity.
Detailed Description
Individuals who have sustained a heart attack are at considerable risk for future cardiac events. A cardiac rehabilitation and exercise program can reduce this risk but it remains a challenge to adopt optimum lifestyle changes. We will determine whether providing individuals with information on leukocyte telomere length, will motivate them to improve their exercise performance. We will test whether professionally conveying this information will stimulate an individual to adhere to proven cardiac prevention strategies, looking at the extent to which one's exercise capacity improves over time.
Investigators
Geoffrey Pickering MD PhD
Professor
Western University, Canada
Eligibility Criteria
Inclusion Criteria
- •Individuals who have sustained a myocardial infarction and entered the cardiac rehabilitation program
Exclusion Criteria
- •Individuals with genetic mutations that affect telomere length
- •Individuals who may not have the mental capacity to understanding the ramifications of risk biomarkers
Outcomes
Primary Outcomes
Exercise capacity based on cardiopulmonary exercise testing
Time Frame: after 6-month cardiac rehabilitation program
Online VO2 maximum
Secondary Outcomes
- Adherence to supervised exercise sessions(6 months)
- Activity assessment(6 months)