Effects of Dark Chocolate on the Risk Factors of Cardiovascular Diseases

Not Applicable

Active, not recruiting

• Conditions: Cardiovascular Diseases

• Registration Number: NCT06808282
• Lead Sponsor: San Diego State University

Brief Summary

Cardiovascular disease (CVD) is the number one cause of death in the US. Epidemiologic evidence supports that antioxidant-rich diets promote health and attenuate or delay the onset of CVD. Cocoa and chocolate products have among the highest antioxidant concentrations compared to other antioxidant food sources. The objective of this study is to examine the effects of regular dark chocolate, bloomed dark chocolate, and white chocolate on cardiovascular health markers.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-04-01
• Study First Submitted: 2025-01-28
• Status Verified: 2025-02
• Study First Submitted QC: 2025-02-03
• Last Update Submitted: 2025-02-03
• Study First Posted: 2025-02-05
• Last Update Posted: 2025-02-05
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Generally healthy subjects

Exclusion Criteria

• Smoker
• Pregnant woman
• Lactose intolerance
• Required dietary supplement use
• Required medication of metabolic disorders
• Allergy to cacao

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change of systolic and diastolic blood pressure	Baseline and Day 15	Change of systolic and diastolic blood pressure will be determined to examine effects of dark chocolate consumption vs white chocolate.
Change of skin blood flow level	Baseline and Day 15	Change of skin blood flow level will be determined using Laser Doppler Flowmetry to examine effects of dark chocolate consumption vs white chocolate. Laser Doppler flowmetry is an optical technology widely used in research to measure blood flow. It is a non-invasive, painless technique for studying microcirculatory changes in tissue.
Change of HDL cholesterol level	Baseline and Day 15	Change of blood cholesterol level will be determined to examine effects of dark chocolate consumption vs white chocolate.
Change of antioxidant levels	Baseline and Day 15	Change of antioxidant levels will be determined to examine effects of dark chocolate consumption vs white chocolate.

Trial Locations

Locations (1)

San Diego State University; 🇺🇸 San Diego, California, United States