Enhancing spontaneous recovery after stroke study (ESPRESSo): A single-site, randomised, controlled, Phase IIa, assessor-blind trial to evaluate the effects of a three week programme of high-intensity, high-dose exploratory arm and hand movements initiated within 1 week of stroke on upper limb motor capacity measured with the Action Research Arm Test..

The University of Auckland0 sites140 target enrollmentStarted: August 31, 2020Last updated: October 3, 2022

Conditions

Trial Snapshot

No summary available.

•i.People with monohemispheric ischaemic stroke or intracerebral haemorrhage confirmed by CT or MRI admitted to Auckland City Hospital within the last 7 days
•ii.First-ever stroke or previous stroke with no upper limb weakness
•iii.At least 18 years old
•iv.Received a Good” or Excellent” prediction from the Predict Recovery Potential (PREP2) algorithm
•v.UE-FM score < 51 at enrolment
•vi.Able to give informed consent
•vii.Patients treated with intravenous thrombolysis and/or intra-arterial thrombectomy are eligible

•i.UE-FM score > 50 at enrolment
•ii.Cognition and/or communication impairment precluding informed consent or engagement with the research procedures, as determined by the patient’s clinical team
•iii.Received a Limited” or Poor” PREP2 prediction
•iv.Inability to sit in a chair and perform upper limb exercises
•v.Life expectancy less than 12 months, as determined by the patient’s clinical team
•vi.Upper limb motor performance limited by pre-existing conditions, such as musculoskeletal disease
•vii.Residing out of region precluding in-person assessment
•viii.Social and/or personal circumstances that interfere with the ability to return for therapy sessions and follow up assessments

Sponsor