Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia: a Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- University Hospital, Antwerp
- Enrollment
- 41
- Locations
- 1
- Primary Endpoint
- Pupillary Reflex Dilation
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
In this study, the pupillary dilation reflex is measured as a nociceptive indicator during elective abdominal surgery under general anesthesia.
Detailed Description
An infrared camera of the video pupillometer measures the pupillary dilation reflex (PDR) in response of a nociceptive stimulus. This autonomic reflex, parasympathetic mediated in sedated patients, can be generated by various pain stimuli (built in standardized protocol, surgical incision, ...) The PDR is a robust reflex, even in patients under general anesthesia, and provides a potential evaluation of the autonomous circuit within the nociceptive evaluation based on pupil dilation upon A-delta and C fibers in both electrical or mechanic stimulation. This mono-centric project involving American Society of Anesthesiologists (ASA) classification I-II patients undergoing elective abdominal surgery under general anesthesia are recruited. Enrolled patients perioperative undergo PDR measurements at four different standardized times.
Investigators
Davina Wildemeersch
MD
University Hospital, Antwerp
Eligibility Criteria
Inclusion Criteria
- •Scheduled abdominal surgery
Exclusion Criteria
- •History of eye deformity, invasive ophthalmologic surgery, impaired pupil reflex in advance
- •Kown cranial nerve(s) deficit
- •Infection of the eye
- •Predicted difficult airway management (DAF Guidelines)
- •Chronic opioid use (\>3 months)
- •Ongoing treatment with beta-blockers, dopamine antagonists, topical atropine
Outcomes
Primary Outcomes
Pupillary Reflex Dilation
Time Frame: Perioperative phase
Pupillary Reflex Dilation is measured four times intraoperatively as a possible indicator of success of analgesia
Secondary Outcomes
- Patient Movement(Perioperative phase)
- Vital signs(Perioperative phase)