ITMCTR2200005496尚未招募1 期
The effect of Buyang Huanwu Decoction on improving the cognitive impairment of diabetic encephalopathy and the molecular mechanism of protecting blood brain barrier
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 年龄范围
- 40 至 80（—）
- 性别
- All
入选标准
- •(1) Patients aged 55 to 75 met the diagnostic criteria for T2DM formulated by WHO in 1999;
- •(2) HbA1c range: 6.5-9%;
- •(3) Conforming to the criteria of TCM syndrome differentiation
- •(4) Montreal Cognitive Assessment Scale (MoCA) score <26 points, complex instrumental daily ability may be slightly impaired, daily living ability normal, does not meet the diagnostic criteria for dementia
- •(5) Able to communicate well with researchers and comply with the requirements of the whole experiment.
- •(6)Other causes of cognitive dysfunction have been ruled out.
排除标准
- •(1) New diseases that may cause blood glucose changes within 3 months, such as infection, myocardial infarction, tumor, inflammation, trauma and other severe stress states, as well as hyperthyroidism, hypothyroidism, hypercortisolism and acromegaly;
- •(2) Cognitive impairment caused by taking drugs that raise blood glucose or improve cognition or neuropsychiatric drugs within 3 months.
- •(3) severe liver disease (including chronic persistent hepatitis, cirrhosis or simultaneous hepatitis B virus surface antigen positive and abnormal liver transaminase (serum alanine aminotransferase or aspartate aminotransferase concentration > 2.5 times the normal upper limit);
- •(4) history of severe kidney disease or serum creatinine & GT; 133 mu mol/l;
- •(5) known diseases of blood system or hemoglobin <90 g/L (9g/dL);
- •(6) hypoproteinemia, serum albumin <35g/L;
- •(7) Blood transfusion or blood donation within the last 3 months;
- •(8) Serious organic diseases, including cancer, coronary heart disease, myocardial infarction or stroke, or cognitive impairment caused by trauma, poisoning, alcoholism, Parkinson's disease, polymyositis, etc.;
- •(9) Assessment of cognitive function affected by severe depression, schizophrenia and other mental diseases or delirium;
- •(10) Infectious diseases, including tuberculosis and AIDS; And alcoholism;
- •(11) Participated in other studies or observational researchers at the same time or within 3 months;
- •(12)Unable to cooperate with the tester for various reasons.
研究者
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