Vitamin -D Supplementation as an Adjunct to Standard Treatment of Asthma in Children: A Randomized Control Trial

Asthma affects up to 15 % children and over a period of time there is increase in incidence.Evidence suggests that Vitamin-D deficiency is associated with increased airway hyper responsiveness, lower pulmonary functions, worse asthma control and possibly steroid resistance. Vitamin-D in lung epithelium inhibit synthesis and release of certain cytokines and decreases lung inflammation , it also have role in innate and adaptive immunity, thus Vitamin-d can help in improvement of asthma control. There are many studies till now with different doses of vitamin-D trial in asthma. Some had positive and some had no results .There are very few studies in India so far and studies done so far only shown to improve respiratory score & acute exacerbation. Pulmonary function indices  are not well studied till date .In our study we have chosen adequate dose of vitamin-D and pulmonary function parameters like FEV1, fraction excretion of  Nitirc oxide will be studied and compared to placebo. so our study will add on the effect of vitamin -D on these pulmonary function inidices.  Vitamin-D baseline level at enrollment and At the end of 3 months  after supplementation  will be compared along with other parameters. As our study include serum Vitamin-D levels and PFTs , it will be add on to existing knowledge and may cover-up the scope of research which is still need to be evaluated for VItamin-D and Asthma control.