Quality control of antibiotic stewardship
- Conditions
- ower respiratory tract infection (LRTI)Respiratory
- Registration Number
- ISRCTN48029287
- Lead Sponsor
- niversity Hospital of Basel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 740
1. Age =18 years
2. Clinical indication for diagnostic bronchoscopy with bronchoalveolar lavage
3. Suspicion of lower respiratory tract infection – in immunocompetent patients infiltrate must be confirmed; in immunocompromised patients an infiltrate is not required
4. Evidence of systemic inflammation (such as abnormal white blood cell count – either leukocytosis (>10.0x10e9/l) or leukopenia (<4.0x10e9/l) – or C-reactive protein (CRP) or procalcitonin (PCT) values above the local upper limit
1. Ambulatory patients
2. Patients intubated at the time of inclusion
3. Neutropenic patients as defined by neutrophils <0.5x10e9/l
4. Haemodynamic instability or signs of life-threatening infection precluding a narrowing of antimicrobial therapy
5. Prior enrolment in an intervention study within the last 30 days
6. Women who are pregnant or breastfeeding
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method