ISRCTN17061437已完成不适用
Comparison of the effectiveness and tolerability of different doses of intravenous glucocorticoid for the treatment of moderately severe Graves' ophthalmopathy - EUGOGO study C
Academic Medical Centre (AMC) (The Netherlands)0 个研究点目标入组 159 人开始时间: 2006年2月14日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 159
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Graves' hyperthyroidism, euthyroid for at least two months by antithyroid drugs or surgery (at least 6 months if I131 is used)
- •2. Moderately severe Graves' ophthalmopathy defined as having at least one of the following signs:
- •2.1. Class 2b-c
- •2.2. Mono-ocular duction less than 30 degrees
- •2.3. Diplopia Gorman score grade a-c
- •3. Active Graves' ophthalmopathy (Clinical Activity Score [CAS] 3 or higher out of 7)
- •4. No past treatment of the ophthalmopathy except for local measures
- •5. Aged 18 - 70 years
排除标准
- •1. CAS less than 3
- •2. Clinically relevant optic nerve involvement
- •3. General contra-indications to glucocorticoid infusions
- •4. Pregnancy
- •5. No informed consent
- •6. Viral hepatitis
- •7. Liver enzymes increased by a factor of 2
研究者
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