Motor Evoked Potentials With Modified Facilitation Technique

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Diagnostic Test: MEP using standard facilitation technique; Diagnostic Test: MEP using modified facilitation technique

• Registration Number: NCT03646929
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

Investigating the change in Test- Retest- reliability in healthy individuals when applying a modified easy to use facilitation technique compared to standard facilitation technique and analyzing sensitivity and specificity in patients with multiple sclerosis regarding detection of pathologic results

Detailed Description

Not available

Study Timeline

• Study Start: 2017-12-20
• Study First Submitted: 2018-08-22
• Study First Submitted QC: 2018-08-22
• Study First Posted: 2018-08-24
• Primary Completion: 2019-01-15
• Study Completion: 2019-01-15
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-04
• Last Update Posted: 2021-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

Not provided

Exclusion Criteria

• Contraindication for measuring of motoric evoked potentials (MEP): metal implants (pacemaker, stents); known epilepsy oder previous epileptic fit
• Known disease of the peripheral nervous system (polyneuropathy)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
healthy individuals and patients with multiple sclerosis	MEP using standard facilitation technique	MEP in healthy individuals and patients with multiple sclerosis are measured using standard facilitation technique
patients with multiple sclerosis	MEP using standard facilitation technique	MEP in patients with multiple sclerosis are measured using modified facilitation technique
patients with multiple sclerosis	MEP using modified facilitation technique	MEP in patients with multiple sclerosis are measured using modified facilitation technique

Primary Outcome Measures

Name	Time	Method
Change in Test- Re-Test reliability when using modified facilitation technique (compared to standard facilitation technique) in healthy individuals	measuring time 2 (75 minutes) maximal 1 month later than measuring time 1 (75 minutes)	Determination of mean intra-individual difference between measuring time 1 and measuring time 2 and calculation of standard deviation
comparison of sensitivity and specificity of modified facilitation technique and standard facilitation technique in patients with multiple sclerosis	1 measuring time (90 minutes)	Determination on the basis of the standard values (established in healthy individuals) in how many patients a pathological result with the modified facilitation technique and the standard facilitation technique is present. Using a a cross-tabulation, the sensitivity and specificity of the modified facilitating technique compared to the standard facilitation technique is measured

Trial Locations

Locations (1)

Dep. of Neurology and Clinical Neurophysiology , Hospital of the University of Basel; 🇨🇭 Basel, Switzerland