A Randomized Controlled Trial to Evaluate Efficacy of Nebulized Hypertonic Saline vs. Normal Saline in the Treatment of Hospitalized Children With Bronchiolitis
Overview
- Phase
- Not Applicable
- Intervention
- Hypertonic saline
- Conditions
- Bronchiolitis
- Sponsor
- Hospital General de Niños Pedro de Elizalde
- Enrollment
- 82
- Locations
- 1
- Primary Endpoint
- Hospitalization Days
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the efficacy of hypertonic saline vs. normal saline in the treatment of infants hospitalized for bronchiolitis, regarding length of hospital stay, oxygen requirements and clinical outcome.
Detailed Description
Despite bronchiolitis is a very frequent disease among infants, there are still controversies regarding its treatment. Hypertonic saline has been proposed as useful treatment in these children, bur information is still controversial. The aim is to asses that using Nebulized Hypertonic Saline with bronchodilators (albuterol) may reduce the days of hospitalization and improve clinical outcomes in patients with acute bronchiolitis, compared with using Normal Saline with albuterol.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Chronic respiratory or cardiovascular disease, respiratory failure.
Arms & Interventions
Hypertonic
Nebulized hypertonic saline (sodium chloride 3%) + albuterol
Intervention: Hypertonic saline
Normal
Normal saline (sodium chloride 0.9%) + albuterol
Intervention: Normal saline
Outcomes
Primary Outcomes
Hospitalization Days
Time Frame: Participants will be followed for the duration of hospitalization, an expected average of 4 days
hospitalization days
Secondary Outcomes
- Length of Oxygen Use(Participants will be followed for the duration of hospitalization, an expected average of 4 days)