Ibuprofen Use on Post-operative Pain Following Cholecystectomy
Overview
- Phase
- Phase 4
- Intervention
- Acetaminophen 100 MG/ML
- Conditions
- Acute Post-operative Pain
- Sponsor
- Giresun University
- Enrollment
- 71
- Locations
- 1
- Primary Endpoint
- VAS scores in the postoperative period
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy. Participants in Group I (group ibuprofen, n=35) were administered 800 mg of IV ibuprofen; participants in Group A (group acetaminophen, n=36) were administered 1000 mg of IV acetaminophen.
Detailed Description
Ibuprofen is a widely used NSAID that has antipyretic, analgesic, and anti-inflammatory effects. In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.The participants in this study were randomized into two groups. Participants in Group I (group ibuprofen, n=35) were administered 800 mg of IV ibuprofen; participants in Group A (group acetaminophen, n=36) were administered 1000 mg of IV acetaminophen. The investigators recorded demographic data including gender, age, ASA, BMI, duration of anesthesia and surgery, poNV, LOS, VAS scores and opioid consumption postoperatively.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA grade I-II patients
- •Aged 18-65 years
Exclusion Criteria
- •History of allergies or hypersensitivity to the aforementioned agents
- •Renal, hepatic or gastrointestinal disease
- •Significant cognitive impairment
- •Recent use of long-term nonsteroid anti-inflammatory and opioids
- •Oral anticoagulant use or known bleeding disorders
- •Diabetes or any other neuropathic diseases
- •Pregnancy or breastfeeding
Arms & Interventions
Acetaminophen group
The acetaminophen group (n=35) received 1000 of mg acetaminophen intravenously in 100 mL saline at the end of the cholecystectomy.
Intervention: Acetaminophen 100 MG/ML
Ibuprofen group
The ibuprofen group (n=36) was administered 800 mg of ibuprofen at the end of the cholecystectomy.
Intervention: Ibuprofen 400 mg
Outcomes
Primary Outcomes
VAS scores in the postoperative period
Time Frame: 24 hour
Primary outcome was to reduce the VAS scores in the postoperative period. For this purpose the investigators recorded VAS scores at the 1, 2, 6, 12 and 24 h postoperatively.
Secondary Outcomes
- Opioid consumption and length of stay(24 hour)